Lomustina [INN-Spanish]

• Antineoplastic Agents
• ATC:L01AD02

• Belustine
• CCNU
• CINU
• Cecenu
• CeeNU
• Chloroethylcyclohexylnitrosourea
• Lomustina [INN-Spanish]
• Lomustinum [INN-Latin]

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C₉H₁₆ClN₃O₂

http://www.rxlist.com/cgi/generic2/lomustine.htm

Lomustina_[INN-Spanish] MSDS

Johnston, TP et al;. J. Med;. 9; 892-911 (1966)

233.695 g/mol

88-90 ^oC

111 mg / L

Solid

2.629

Capsules (10 mg, 40 mg et 100 mg)

Principalement indiquée pour le traitement des tumeurs cérébrales. Aussi pour le traitement du cancer du sein, maladie de Hodgkin, le cancer du poumon, le mélanome malin, le myélome multiple, les lymphomes non-hodgkiniens, le cancer de l'ovaire, le cancer du pancréas et le cancer des cellules rénales.

Lomustine est un agent alkylant de type nitrosourée. Lomustine et de ses métabolites interfère avec la fonction de l'ADN et l'ARN. C'est la phase du cycle cellulaire non spécifique. Cancers forment lorsque certaines cellules dans le corps multiplie de façon incontrôlée et anormale. Ces cellules ont ensuite se propager et détruire les tissus voisins. Lomustine agit en ralentissant le processus vers le bas. Il tue les cellules cancéreuses en endommageant l'ADN (le patrimoine génétique matériau à l'intérieur des cellules) et les empêche de se diviser.

Eh bien et rapidement absorbé par le tractus gastro-intestinal.

Voie orale, rat: DL50 = 70 mg / kg. La toxicité pulmonaire ont été rapportés à des doses cumulatives généralement supérieure à 1100 mg/m2. Il ya un rapport de toxicité pulmonaire, à une dose cumulative de seulement 600 mg. L' l'apparition de la toxicité a varié de 6 mois après l'initiation du traitement, à aussi tard que 15 ans après.

Lomustine (loe-MUS-teen) is a drug that is used to treat some kinds of cancer.
It is a capsule that you take by mouth.
A blood sample will be taken before each treatment. The dose and timing of your
chemotherapy may be changed based on your blood counts and/or other side effects.
It is important to take lomustine exactly as directed by your doctor. Make sure
you understand the directions. You may be given capsules of more than one strength
to make the right dose. Unless your doctor gives you other directions, take all
the capsules as a single dose at bedtime (on an empty stomach with a glass of water).
If you vomit within 45 minutes of taking lomustine, call your cancer doctor the
next morning.
Store lomustine capsules out of the reach of children, at room temperature, away
from heat, light and moisture.
Other drugs may interact with lomustine. Check with your doctor or pharmacist before
you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or usefulness
of lomustine.
Lomustine may cause sterility in men and menopause in women which may be permanent.
If you plan to have children, discuss this with your doctor before being treated with
lomustine.
Lomustine may damage sperm and may harm the baby if used during pregnancy. It is best
to use birth control while being treated with lomustine. Tell your doctor right away
if you or your partner becomes pregnant. Do not breast feed during treatment.
Tell doctors or dentists that you are taking lomustine before you receive any treatment
from them.

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